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From Sequence Data incl. Orthologs, Paralogs, and Xenologs to Gene and Species Trees

Abstract: 
Phylogenetic reconstruction aims at finding plausible hypotheses of the evolutionary history of genes or species based on genomic sequence information. The distinction of orthologous genes (genes having a common ancestry and diverged after a speciation) is crucial and lies at the heart of many genomic studies. However, existing methods that rely only on 1:1 orthologs to infer species trees are strongly restricted to a small set of allowed genes that provide information about the species tree. The use of larger gene sets that additionally consist of non-orthologous genes (e.g., so-called paralogous or xenologous genes) considerably increases the information about the evolutionary history of the respective species. In this work, we introduce a novel method to compute species phylogenies based on sequence data including orthologs, paralogs, or even xenologs.
Journal: 
Evolutionary Biology
Publication Date: 
21 Sep 2016
Citation: 
[HW16] Hellmuth, M., and Wieseke, N.: From Sequence Data incl. Orthologs, Paralogs, and Xenologs to Gene and Species Trees. Chapter in Evolutionary Biology: Convergent Evolution, Evolution of Complex Traits, Concepts and Methods, Ed. Pierre Pontarotti, Springer, p. 373-392, ISBN 978-3-319-41323-5, 2016
Researchers: