MOTIVATION:
Transcriptional regulators play a major role in most biological processes. Alterations in their activities are associated with a variety of diseases and in particular with tumor development and progression. Hence, it is important to assess the effects of deregulated regulators on pathological processes.
RESULTS:
Here, we present REGGAE (REGulator-Gene Association Enrichment), a novel method for the identification of key transcriptional regulators that have a significant effect on the expression of a given set of genes, e.g.