Tim Kehl
Employment:
Researcher
Personal:
My name is Tim Kehl and I am a researcher at the chair of Prof. Dr. Hans-Peter Lenhof. We are developing new algorithms, software and databases for the analysis of human pathologies, especially cancer. In particular, I am interested in the analysis of deregulated signaling pathways as well as the identification of novel biomarkers.
Education:
- M.Sc. Computational Molecular Biology / Bioinformatics, Saarland University, May 2015
- B.Sc. Computational Molecular Biology / Bioinformatics, Saarland University, June 2013
Research:
- Cancer research
- Enrichment analysis
- miRNAs
- Network analysis
- Regulatory genomics
- Systems biology
Teaching:
Lectures:
- Bioinformatics I : WS15/16, WS16/17, WS17/18, WS18/19
- Bioinformatics II : SS15, SS16, SS17, SS18
- Effizientes Lernen : WS15/16, WS16/17, WS17/18, WS18/19
Seminars:
- Proseminar "Bioinformatic Approaches for Cancer Research" : SS15
- Proseminar "Bioinformatic Approaches for Personalized Cancer Treatment" : WS15/16, SS16, WS16/17, SS17, WS17/18, SS18, WS18/19
- Proseminar "Bioinformatic Approaches for Regulatory Genomics" : SS18, WS18/19
- Seminar "Computational Systems Biology of Cancer" : WS16/17, SS17, WS17/18, SS18, WS18/19
- Seminar "Inferring Network Structure from Data" : SS15
- Seminar "Machine Learning" : SS18
- Proseminar "Pathway and Network Analysis in Cancer Research " : WS16/17, SS17,
- Seminar "Probabilistic graphical models in disease" : WS15/16, SS16,
My Publications
2019
[SKT+19] Schneider L, Kehl T, Thedinga K, Grammes NL, Backes C, Mohr C, Schubert B, Lenhof K, Gerstner N, Hartkopf AD, Wallwiener M, Kohlbacher O, Keller A, Meese E, Graf N, Lenhof HP. ClinOmicsTrail bc: a visual analytics tool for breast cancer treatment stratification, Bioinformatics, btz302, 2019.
2018
[FLB+18] Fehlmann T, Laufer T, Backes C, Kahramann M, Alles J, Fischer U, Minet M, Ludwig N, Kern F, Kehl T, Galata V, Düsterloh A, Schrörs H, Kohlhaas J, Bals R, Huwer H, Geffers L, Krüger R, Balling B, Lenhof HP, Meese E, Keller A. Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity. RNA Biology, Dec 2018.
[KSK+18] Kehl T, Schneider L, Kattler K, Stöckel D, Wegert J, Gerstner N, Ludwig N, Distler U, Tenzer S, Gessler M, Walter J, Keller A, Graf N, Meese E, Lenhof HP. The role of TCF3 as potential master regulator in blastemal Wilms tumors. International Journal of Cancer. (in production).
[KSK+18] Kehl T, Schneider L, Kattler K, Stöckel D, Wegert J, Gerstner N, Ludwig N, Distler U, Schick M, Keller U, Tenzer S, Gessler M, Walter J, Keller A, Graf N, Meese E, Lenhof HP. REGGAE: a novel approach for the identification of key transcriptional regulators. Bioinformatics. 2018 May 7. doi: 10.1093/bioinformatics/bty372.
2017
[KBK+17] Kehl T, Backes C, Kern F, Fehlmann T, Ludwig N, Meese E, Lenhof HP, Keller A. About miRNAs, miRNA seeds, target genes and target pathways. Oncotarget. 2017 Nov 9;8(63):107167-107175. doi: 10.18632/oncotarget.22363. eCollection 2017 Dec 5.
[BFK+17] Backes C, Fehlmann T, Kern F, Kehl T, Lenhof HP, Meese E, Keller A. miRCarta: a central repository for collecting miRNA candidates. Nucleic acids research 46 (D1), D160-D167. doi: 10.1093/nar/gkx851.
[KSS+17] Kehl T, Schneider L, Schmidt F, Stöckel D, Gerstner N, Backes C, Meese E, Keller A, Schulz MH, Lenhof HP. RegulatorTrail: a web service for the identification of key transcriptional regulators. Nucleic Acids Res. 2017 Jul 3;45(W1):W146-W153. doi: 10.1093/nar/gkx350.
[BKS+17] Backes C., Kehl T., Stöckel D., Fehlmann T., Schneider L., Meese E., Lenhof H.-P., Keller A. miRPathDB: a new dictionary on microRNAs and target pathways. Nucleic Acids Res. 2017 Jan 4;45(D1):D90-D96. doi: 10.1093/nar/gkw926
2016
[SSK+16] Schneider, L., Stöckel, D., Kehl, T., Gerasch, A., Ludwig, N., Leidinger, P., Huwer, H., Tenzer, S., Kohlbacher, O., Hildebrandt, A., Kaufmann, M., Gessler, M., Keller, A., Meese, E., Graf, N., and Lenhof, H.-P.: DrugTargetInspector: An assistance tool for patient treatment stratification.
Int J Cancer. 2016 Apr 1;138(7):1765-76. doi: 10.1002/ijc.29897.
[SKT+16] Stöckel, D., Kehl, T., Trampert, P., Schneider, L., Backes, C., Ludwig, N., Gerasch, A., Kaufmann, M., Gessler, M., Graf, N., Meese, E., Keller, A., Lenhof, H.P.,: Multi-omics Enrichment Analysis using the GeneTrail2 Web Service. Bioinformatics 2016; doi: 10.1093/bioinformatics/btv770
2013
[SMK+13] Stöckel, D., Müller, O., Kehl, T., Gerasch, A., Backes, C., Rurainski, A., Keller, A., Kaufmann, M., and Lenhof, H.-P.: NetworkTrail - A web service for identifying and visualizing deregulated subnetworks. Bioinformatics 29 (13):1702-03, 2013.
