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Prof. Dr. Hans-Peter Lenhof

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This is the personal page of Hans-Peter Lenhof

My Publications

2022

[LEG+22] Lenhof, K., Eckhart, L., Gerstner, N., Kehl, T., Lenhof, H.-P. Simultaneous regression and classification for drug sensitivity prediction using an advanced random forest method. Scientific Reports, 2022. DOI: 10.1038/s41598-022-17609-x.
[VKK+22] Vardapour, R., Kehl, T., Kneitz; S., Ludwig, N., Meese, E., Lenhof, H.-P., Gessler, M. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes, Oxford Academic Carcinogenesis, 2022. DOI: 10.1093/carcin/bgab110.
[SZM+22] Schick, M., Zhang, L.,Maurer, S., Maurer, H. C., Isaakaidis, K., Schneider, L., Patra, U., Schunck, K., Rohleder, E., Hofstetter, J., Baluapuri, A., Scherger, A.K., Slotta-Huspenina, J., Hettler, F., Weber, J., Engleitner, T., Maresch, R., Slawska, J., Lewis, R., Istvanffy, R., Habringer, S., Steiger, K., Baiker, A., Oostendorp, R.A.J., Miething, C., Lenhof, H.-P., Bassermann, F., Chapuy, B., Wirth, M., Wolf, E., Rad, R., Müller, S., Keller, U. Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Nature Communications, 2022. DOI: 10.1038/s41467-021-27704-8.

2021

[VKK+2021] Vardapour, R., Kehl, T., Kneitz, S., Ludwig, N., Meese, E., Lenhof, H.-P., Gessler, M. The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes. Oxford Academic Carcinogenesis, 2021. DOI: 10.1093/carcin/bgab110.
[GKL+21] Gerstner, N., Kehl, T., Lenhof, K., Eckhart, L., Schneider, L., Stöckel, D., Backes, C., Meese, E., Keller, A., Lenhof, H.-P. GeneTrail: A Framework for the Analysis of High-Throughput Profiles. Frontiers in Molecular Biosciences, 2021. DOI: 10.3389/fmolb.2021.716544.
[LGK+21] Lenhof, K., Gerstner, N., Kehl, T., Eckhart, L., Schneider, L., Lenhof, H.-P. MERIDA: a novel Boolean logic-based integer linear program for personalized cancer therapy. Bioinformatics, btab 546, 2021. DOI: 10.1093/bioinformatics/btab546.
[KPL+21] Kern, F., Aparicio-Puerta, E., Li, Y., Fehlmann, T., Kehl, T., Wagner, V., Ray K., Ludwig N., Lenhof, H.-P., Meese, E., Keller A. miRTargetLink 2.0—interactive miRNA target gene and target pathway networks. Nucleic Acids Research, 2021. DOI: org/10.1093/nar/gkab297.
[KKD+21] Kern, F., Krammes, L., Danz, K., Diener, C., Kehl, T., Küchler, O., Fehlmann, T., Kahraman, M., Rheinheimer, S., Aparicio-Puerta, E., Wagner, S., Ludwig, N., Backes, C., Lenhof, H.-P., von Briesen, H., Hart, M., Keller, A., Meese, E. Validation of human microRNA target pathways enables evaluation of target prediction tools. Nucleic Acids Research, 2021. DOI: 10.1093/nar/gkaa1161.

2020

[HNW-R20] Hart, M., Nickl, L., Walch-Rueckheim, B., Krammes, L., Rheinheimer, S., Diener, C.,Taenzer, T., Kehl, T., Sester, M., Lenhof, H.-P., Keller, A., Meese, E. Wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4+, CD8+ T cells, and M1 macrophages. Journal for ImmunoTherapy of Cancer, 2020. DOI: 10.1136/jitc-2020-001617.
[DHK+20] Diener, C., Hart, M., Kehl, T., Rheinheimer, S., Ludwig, N.,Krammes, L., Pawusch, S., Lenhof, K., Tänzer, T., Schub, D., Sester, M., Walch-Rückheim,B., Keller, A., Lenhof, H.-P., Meese, E. Quantitative and time-resolved miRNA pattern of early human T cell activation. Nucleic Acids Research, 2020. DOI: 10.1093/nar/gkaa788.
[GKL+20] Gerstner, N., Kehl, T., Lenhof, K., Müller, A., Mayer, C., Eckhart, L., Grammes, N.L., Diener, C., Hart, M., Hahn, O., Walter, J., Wyss-Coray, T., Meese, E., Keller, A., Lenhof, H.-P. GeneTrail 3: advanced high-throughput enrichment analysis. Nucleic Acids Research, 2020. DOI:10.1093/nar/gkaa306.
[FKL+20] Fehlmann, T., Kahraman, M., Ludwig, N., Backes, C., Galata, V., Keller, V., Geffers, L., Mercaldo, N., Hornung, D., Weis, T., Kayvanpour, E., Abu-Halima, M., Deuschle, C., Schulte, C., Suenkel, U., von Thaler, A.-K., Maetzler, W., Herr, C., Fähndrich, S., Vogelmeier, C., Guimaraes, P., Hecksteden, A., Meyer, T., Metzger, F., Diener, C., Deutscher, S., Abdul-Khaliq, H., Stehle, I., Haeusler, S., Meiser, A., Groesdonk, H.-V., Volk, T., Lenhof,, H.-P., Katus, H., Balling, R., Meder, B., Kruger, R., Huwer, H., Bals, R., Meese, E., Keller, A. Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients. JAMA Oncology, 2020. DOI: 10.1001/jamaoncol.2020.0001.
[BHS+20] Biederstädt, A., Zonera, H., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L.,Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H.-P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Müller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. GUT, Januar 2020. DOI: 10.1136/gutjnl-2018-317856.

2019

[LFK+19] Ludwig, N., Fehlmann, T., Kern, F., Gogol, M., Maetzler, W., Deutscher, S., Gurlit, S.,Schulte,C.,vonThaler, A.-K., Deuschle, C., Metzger, F., Berg, D., Suenkel, U., Keller, V., Backes, C., Lenhof, H.-P., Meese, E., Keller, A. Machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs. Genomics, Proteomics & Bioinformatics, 2019. DOI:10.1016/j.gpb.2019.09.004.
[KKB+19] Kehl, T., Kern, F., Backes, C., Fehlmann, T., Stöckel, D., Meese, E., Lenhof, H.-P., Keller, A. miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database. Nucleic Acids Research, Dezember 2019. DOI: 10.1093/nar/gkz1022.
[KLF+19] Keller, A., Ludwig, N., Fehlmann, T., Kahraman, M., Backes, C., Kern, F., Vogelmeier, CF., Diener, C., Fischer, U., Biertz, F., Herr, C., Jörres, RA., Lenhof, H.-P., Bals, R., Meese, E.Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. Cells 2019, 8(10), 1162; DOI:10.3390/cells8101162.
[HWK+19] Hart, M., Walch-Rückheim, B., Krammes, K., Kehl, T., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H.-P., Keller, A., Meese, E. miR-34a as hub of T cell regulation networks. Journal for Immunotherapy of Cancer 7 (1), 187, 2019. DOI: 10.1186/s40425-019-0670-5.
[SKT+19] Schneider, L., Kehl, T., Thedinga, K., Grammes, N. L., Backes, C., Mohr, C., Schubert, B., Lenhof, K., Gerstner, N., Hartkopf. A. D., Wallwiener, M., Kohlbacher, O., Keller, A., Meese, E., Graf, N., Lenhof, H.-P. ClinOmicsTrail bc: a visual analytics tool for breast cancer treatment stratification, Bioinformatics, btz302, 2019. DOI: 10.1093/bioinformatics/btz302.
[FBP+19] Fehlmann, T., Backes, C., Pirritano, M., Laufer, T., Galata, V., Kern, F., Kahraman, M., Gasparoni, G., Ludwig, N., Lenhof, H.-P., Gregersen, H., Francke, R., Meese, E., Simon, M., Keller, A. The sncRNA Zoo: a repository for circulating small noncoding RNAs in animal. Nucleic Acids Research 47 (9), 4431-4441, 2019. DOI: 10.1093/nar/gkz227.
[KSK+19] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. The role of TCF3 as potential master regulator in blastemal Wilms tumors. International Journal of Cancer 144 (6), 1432-1443, 2019. DOI: 10.1002/ijc.31834.
[AFF+19] Alles, J., Fehlmann, T., Fischer, U., Backes, C., Galata, V., Minet, M., Har, M., Abu-Halima, M., Grässer. F.A., Lenhof, H.-P., Keller, A., Meese, E. An estimate of the total number of true human miRNAs. Nucleic Acids Research 47 (7), 3353-3364, 2019. DOI: 10.1093/nar/gkz097.
[HWF+19] Hart, M., Walch-Rückheim, B., Friedmann, K.S., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H.-P., Hoth, M., Schwarz, E.C., Keller, A., Meese, E. miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling. Cell Death & Disease 10 (2), 46, 2019. DOI: 10.1038/s41419-018-1295-1.
[FLB+19] Fehlmann, T., Laufer, T., Backes, C., Kahramann, M., Alles, J., Fischer, U., Minet, M., Ludwig, N., Kern, F., Kehl, T., Galata, V., Düsterloh, A., Schrörs, H., Kohlhaas, J., Bals, R., Huwer, H., Geffers, L., Krüger, R., Balling, B., Lenhof, H.-P., Meese, E., Keller, A. Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity. RNA Biology 16 (1), 93-103, 2019. DOI: 10.1080/15476286.2018.1559689.

2018

[DHA+18] Diener, C., Hart, M., Alansary, D., Poth, V., Walch-Rückheim, B., Menegatti, J., Grässer, F., Fehlmann, T., Rheinheimer, S., Niemeyer, B.A., Lenhof, H.-P., Keller, A., Meese, E. Modulation of intracellular calcium signaling by microRNA-34a-5p. Cell Death & Disease 9 (10), 1008, 2018. DOI: 10.1038/s41419-018-1050-7.
[KFL+18] Keller, A., Fehlmann, T., Ludwig, N., Kahraman, M., Laufer, T., Backes, C., Vogelmeier, C., Diener, C., Biertz, F., Herr, C., Jörres, R.A., Lenhof, H.-P., Meese, E., Bals, R., COSYCONET Study Group.Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development. Genomics, Proteomics & Bioinformatics 16 (3), 162-171, 2018. DOI: 10.1016/j.gpb.2018.06.001.

Pages

Contact

Address:
Center for Bioinformatics
Saarland Informatics Campus
Saarland University
Building E 2.1
Room 416
P.O. Box 15 11 50
66041 Saarbrücken
Germany
Email:
len@bioinf.uni-sb.de
Fax:
+49-681-302-64719
Phone:
+49-681-302-64701