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Prof. Dr. Hans-Peter Lenhof

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This is the personal page of Hans-Peter Lenhof

My Publications

2019

[HWK+19] Hart, M., Walch-Rückheim, B., Krammes, K., Kehl, T., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H.-P., Keller, A., Meese, E. miR-34a as hub of T cell regulation networks. Journal for immunotherapy of cancer 7 (1), 187, 2019. DOI: 10.1186/s40425-019-0670-5.
[SKT+19] Schneider, L., Kehl, T., Thedinga, K., Grammes, N. L., Backes, C., Mohr, C., Schubert, B., Lenhof, K., Gerstner, N., Hartkopf. A. D., Wallwiener, M., Kohlbacher, O., Keller, A., Meese, E., Graf, N., Lenhof, H.-P. ClinOmicsTrail bc: a visual analytics tool for breast cancer treatment stratification, Bioinformatics, btz302, 2019. DOI: 10.1093/bioinformatics/btz302.
[FBP+19] Fehlmann, T., Backes, C., Pirritano, M., Laufer, T., Galata, V., Kern, F., Kahraman, M., Gasparoni, G., Ludwig, N., Lenhof, H.-P., Gregersen, H., Francke, R., Meese, E., Simon, M., Keller, A. The sncRNA Zoo: a repository for circulating small noncoding RNAs in animal. Nucleic acids research 47 (9), 4431-4441, 2019. DOI: 10.1093/nar/gkz227.
[KSK+19] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. The role of TCF3 as potential master regulator in blastemal Wilms tumors. International journal of cancer 144 (6), 1432-1443, 2019. DOI: 10.1002/ijc.31834.
[AFF+19] Alles, J., Fehlmann, T., Fischer, U., Backes, C., Galata, V., Minet, M., Har, M., Abu-Halima, M., Grässer. F.A., Lenhof, H.-P., Keller, A., Meese, E. An estimate of the total number of true human miRNAs. Nucleic acids research 47 (7), 3353-3364, 2019. DOI: 10.1093/nar/gkz097.
[HWF+19] Hart, M., Walch-Rückheim, B., Friedmann, K.S., Rheinheimer, S., Tänzer, T., Glombitza, B., Sester, M., Lenhof, H.-P., Hoth, M., Schwarz, E.C., Keller, A., Meese, E. miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling. Cell death & disease 10 (2), 46, 2019. DOI: 10.1038/s41419-018-1295-1.
[FLB+19] Fehlmann, T., Laufer, T., Backes, C., Kahramann, M., Alles, J., Fischer, U., Minet, M., Ludwig, N., Kern, F., Kehl, T., Galata, V., Düsterloh, A., Schrörs, H., Kohlhaas, J., Bals, R., Huwer, H., Geffers, L., Krüger, R., Balling, B., Lenhof, H.-P., Meese, E., Keller, A. Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity. RNA biology 16 (1), 93-103, 2019. DOI: 10.1080/15476286.2018.1559689.

2018

[DHA+18] Diener, C., Hart, M., Alansary, D., Poth, V., Walch-Rückheim, B., Menegatti, J., Grässer, F., Fehlmann, T., Rheinheimer, S., Niemeyer, B.A., Lenhof, H.-P., Keller, A., Meese, E. Modulation of intracellular calcium signaling by microRNA-34a-5p. Cell death & disease 9 (10), 1008, 2018. DOI: 10.1038/s41419-018-1050-7.
[KFL+18] Keller, A., Fehlmann, T., Ludwig, N., Kahraman, M., Laufer, T., Backes, C., Vogelmeier, C., Diener, C., Biertz, F., Herr, C., Jörres, R.A., Lenhof, H.-P., Meese, E., Bals, R., COSYCONET Study Group.Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development. Genomics, proteomics & bioinformatics 16 (3), 162-171, 2018. DOI: 10.1016/j.gpb.2018.06.001.
[KSK+18] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Schick, M., Keller, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. REGGAE: a novel approach for the identification of key transcriptional regulators. Bioinformatics. Bioinformatics 34 (20), 3503-3510, 2018. DOI: 10.1093/bioinformatics/bty372.

2017

[FBA+17] Fehlmann, T., Backes, C., Alles, J., Fischer, U., Hart, M., Kern, F., Langseth, H., Rounge, T., Umu, S.U., Kahraman, M., Laufer, T., Haas, J., Staehler, C., Ludwig, N., Hübenthal, M., Meder, B., Franke, A., Lenhof, H.-P., Meese, E., Keller, A. A high-resolution map of the human small non-coding transcriptome. Bioinformatics 34 (10), 1621-1628, 2017. DOI: 10.1093/bioinformatics/btx814.
[KBK+17] Kehl, T., Backes, C., Kern, F., Fehlmann, T., Ludwig, N., Meese, E., Lenhof, H.-P., Keller, A. About miRNAs, miRNA seeds, target genes and target pathways. Oncotarget 8 (63), 107167, 2017. DOI: 10.18632/oncotarget.22363.
[BFK+17] Backes, C., Fehlmann, T., Kern, F., Kehl, T., Lenhof, H.-P., Meese, E., Keller, A. miRCarta: a central repository for collecting miRNA candidates. Nucleic acids research 46 (D1), D160-D167, 2017. DOI: 10.1093/nar/gkx851.
[KSS+17] Kehl, T., Schneider, L., Schmidt, F., Stöckel, D., Gerstne,r N., Backes, C., Meese, E., Keller, A., Schulz, M.H., Lenhof, H.-P. RegulatorTrail: a web service for the identification of key transcriptional regulators. Nucleic acids research 45 (W1), W146-W153, 2017. DOI: 10.1093/nar/gkx350.
[BKS+17] Backes C., Kehl T., Stöckel D., Fehlmann T., Schneider L., Meese E., Lenhof H.-P., Keller A. miRPathDB: a new dictionary on microRNAs and target pathways. Nucleic Acids Res. 2017 Jan 4;45(D1):D90-D96. doi: 10.1093/nar/gkw926

2016

[BLL+16] Backes, C., Ludwig, N., Leidinger, P., Huwer, H., Tenzer, S., Fehlmann, T., Franke, A., Meese, E., Lenhof, H.-P., Keller, A. Paired proteomics, transcriptomics and miRNomics in non-small cell lung cancers: known and novel signaling cascades. Oncotarget 7 (44), 71514, 2017. DOI: 10.18632/oncotarget.11723.
[SSK+16] Schneider, L., Stöckel, D., Kehl, T., Gerasch, A., Ludwig, N., Leidinger, P., Huwer, H., Tenzer, S., Kohlbacher, O., Hildebrandt, A., Kaufmann, M., Gessler, M., Keller, A., Meese, E., Graf, N., and Lenhof, H.-P.: DrugTargetInspector: An assistance tool for patient treatment stratification. Int J Cancer. 2016 Apr 1;138(7):1765-76. doi: 10.1002/ijc.29897.
[LWB+16] Ludwig, N., Werner, T.V., Backes, C., Trampert, P., Gessler, M., Keller, A., Lenhof, H.-P., Graf, N., and Meese E.: Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes. Int J Mol Sci. 2016 Mar 30;17(4). pii: E475. doi: 10.3390/ijms17040475.
[TLB+16] Tenzer, S., Leidinger, P., Backes, C., Huwer, H., Hildebrandt, A., Lenhof, H.-P., Wesse, T., Franke, A., Meese, E., and Keller, A.: Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase. Oncotarget. 2016 Feb 22. doi: 10.18632/oncotarget.7562. [Epub ahead of print]
[MBM+16] Marx, A., Backes, C., Meese, E., Lenhof, H.-P., and Keller, A.: EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon-Mann-Whitney Test. Genomics Proteomics Bioinformatics. 2016 Feb;14(1):55-61. doi: 10.1016/j.gpb.2015.11.004. [Epub 2016 Jan 29]
[SKT+16] Stöckel, D., Kehl, T., Trampert, P., Schneider, L., Backes, C., Ludwig, N., Gerasch, A., Kaufmann, M., Gessler, M., Graf, N., Meese, E., Keller, A., Lenhof, H.P.,: Multi-omics Enrichment Analysis using the GeneTrail2 Web Service. Bioinformatics 2016; doi: 10.1093/bioinformatics/btv770

2015

[SST+15] Stöckel, D., Schmidt, F., Trampert, P., and Lenhof, H.-P.: CausalTrail: Testing hypothesis using causal Bayesian networks. F1000Research 2015, 4(ISCB Comm J):1520, doi: 10.12688/f1000research.7647.1
[MBK+15] Mueller, S.C., Backes, C. , Kalinina, O. V., Meder, B., Stöckel, D., Lenhof, H.-P., Meese, E. and Keller, A. BALL-SNP: combining genetic and structural information to identify candidate non-synonymous single nucleotide polymorphisms. Genome Medicine. 2015, 7:65, DOI:10.1186/s13073-015-0190-y
[LKM+15] Leidinger, P., Keller, A., Milchram, L., Harz, C., Hart, M., Werth, A., Lenhof, H.-P., Weinhäusel, A., Keck, B., Wullich, B., Ludwig, N., and Meese, E.: Combination of Autoantibody Signature with PSA Level Enables a Highly Accurate Blood-Based Differentiation of Prostate Cancer Patients from Patients with Benign Prostatic Hyperplasia. PLoS One. 2015 Jun 3;10(6):e0128235. doi: 10.1371/journal.pone.0128235. eCollection 2015.
[LNB+15] Ludwig, N., Nourkami-Tutdibi, N., Backes, C., Lenhof, H.-P., Graf, N., Keller, A., and Meese, E. Circulating serum miRNAs as potential biomarkers for nephroblastoma. Pediatr Blood Cancer, Wiley Periodicals, Inc.; 2015 March 18 doi: 10.1002/pbc.25481. [Epub ahead of print]

Pages

Contact

Address:
Center for Bioinformatics
Saarland University
Building E 2.1
Room 416
P.O. Box 15 11 50
66041 Saarbrücken
Germany
Email:
len@bioinf.uni-sb.de
Fax:
+49-681-302-64719
Phone:
+49-681-302-64701