Lara Schneider
Employment:
Researcher
Personal:
My name is Lara and I am a researcher at the chair of Prof. Dr. Hans-Peter Lenhof. I mainly work in the area of decision support systems for cancer treatment. Two of my projects in this area are DrugTargetInspector and ClinOmicsTrail.
Education:
- Master of Science: Computational Molecular Biology, Saarland University, October 2012
- Bachelor of Science: Computational Molecular Biology, Saarland University, May 2011
Research:
- Personalized medicine
- Cancer research
- Multi-omics integrative analyses
- Treatment decision-making assistance tools
Teaching:
Teaching Assistant:
- Bioinformatics I: WS12/13, WS13/14, WS15/16, WS16/17, WS17/18
- Bioinformatics II: SS13, SS14, SS15, SS16, SS17, SS18
- Proseminar 'Bioinformatic Approaches for Regulatory Genomics': SS18
- Proseminar 'Bioinformatic Approaches for Personalized Cancer Treatment': WS15/16, SS16, WS16/17, SS17, WS17/18, SS18
- Proseminar 'Pathway and Network Analysis in Cancer Research': WS16/17, SS17, WS17/18
- Proseminar 'Bioinformatic Approaches for Cancer Research': WS12/13, SS13, WS13/14, SS14, WS4/15, SS15
- Seminar 'Computational Systems Biology of Cancer': WS16/17, SS17, WS17/18, SS18
- Seminar 'Probabilistic Graphical Models in Disease': WS15/16, SS16
- Seminar 'Inferring Network Structure from Data': SS13, WS13/14, SS14, WS14/15, SS15
- Seminar 'Modeling and Analyzing Biological Networks': WS12/13
Tutor:
- Preparatory Course on Mathematics for Computer Scientists: 2008, 2009
- Programming I: WS08/09
- Programming II: SS09
- Bioinformatics I: WS09/10, WS10/11
My Publications
2022
[SZM+22] Schick, M., Zhang, L.,Maurer, S., Maurer, H. C., Isaakaidis, K., Schneider, L., Patra, U., Schunck, K., Rohleder, E., Hofstetter, J., Baluapuri, A., Scherger, A.K., Slotta-Huspenina, J., Hettler, F., Weber, J., Engleitner, T., Maresch, R., Slawska, J., Lewis, R., Istvanffy, R., Habringer, S., Steiger, K., Baiker, A., Oostendorp, R.A.J., Miething, C., Lenhof, H.-P., Bassermann, F., Chapuy, B., Wirth, M., Wolf, E., Rad, R., Müller, S., Keller, U. Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Communications, 2022. DOI: 10.1038/s41467-021-27704-8.
2021
[GKL+21] Gerstner, N., Kehl, T., Lenhof, K., Eckhart, L., Schneider, L., Stöckel, D., Backes, C., Meese, E., Keller, A., Lenhof, H.-P. GeneTrail: A Framework for the Analysis of High-Throughput Profiles. Frontiers in Molecular Biosciences, 2021. DOI: 10.3389/fmolb.2021.716544.
[LGK+21] Lenhof, K., Gerstner, N., Kehl, T., Eckhart, L., Schneider, L., Lenhof, H.-P. MERIDA: a novel Boolean logic-based integer linear program for personalized cancer therapy. Bioinformatics, btab 546, 2021. DOI: 10.1093/bioinformatics/btab546.
2020
[GKL+20] Gerstner, N., Kehl, T., Lenhof, K., Müller, A., Mayer, C., Eckhart, L., Grammes, N.L., Diener, C., Hart, M., Hahn, O., Walter, J., Wyss-Coray, T., Meese, E., Keller, A., Lenhof, H.-P. GeneTrail 3: advanced high-throughput enrichment analysis. Nucleic Acids Research, 2020. DOI:10.1093/nar/gkaa306.
[BHS+20] Biederstädt, A., Zonera, H., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L.,Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H.-P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Müller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. GUT, Januar 2020. DOI: 10.1136/gutjnl-2018-317856.
2019
[SKT+19] Schneider, L., Kehl, T., Thedinga, K., Grammes, N. L., Backes, C., Mohr, C., Schubert, B., Lenhof, K., Gerstner, N., Hartkopf. A. D., Wallwiener, M., Kohlbacher, O., Keller, A., Meese, E., Graf, N., Lenhof, H.-P. ClinOmicsTrail bc: a visual analytics tool for breast cancer treatment stratification, Bioinformatics, btz302, 2019. DOI: 10.1093/bioinformatics/btz302.
[KSK+19] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. The role of TCF3 as potential master regulator in blastemal Wilms tumors. International Journal of Cancer 144 (6), 1432-1443, 2019. DOI: 10.1002/ijc.31834.
2018
[KSK+18] Kehl, T., Schneider, L., Kattler, K., Stöckel, D., Wegert, J., Gerstner, N., Ludwig, N., Distler, U., Schick, M., Keller, U., Tenzer, S., Gessler, M., Walter, J., Keller, A., Graf, N., Meese, E., Lenhof, H.-P. REGGAE: a novel approach for the identification of key transcriptional regulators. Bioinformatics. Bioinformatics 34 (20), 3503-3510, 2018. DOI: 10.1093/bioinformatics/bty372.
2017
[KSS+17] Kehl, T., Schneider, L., Schmidt, F., Stöckel, D., Gerstne,r N., Backes, C., Meese, E., Keller, A., Schulz, M.H., Lenhof, H.-P. RegulatorTrail: a web service for the identification of key transcriptional regulators. Nucleic Acids Research 45 (W1), W146-W153, 2017. DOI: 10.1093/nar/gkx350.
[BKS+17] Backes C., Kehl T., Stöckel D., Fehlmann T., Schneider L., Meese E., Lenhof H.-P., Keller A. miRPathDB: a new dictionary on microRNAs and target pathways. Nucleic Acids Res. 2017 Jan 4;45(D1):D90-D96. doi: 10.1093/nar/gkw926
2016
[SSK+16] Schneider, L., Stöckel, D., Kehl, T., Gerasch, A., Ludwig, N., Leidinger, P., Huwer, H., Tenzer, S., Kohlbacher, O., Hildebrandt, A., Kaufmann, M., Gessler, M., Keller, A., Meese, E., Graf, N., and Lenhof, H.-P.: DrugTargetInspector: An assistance tool for patient treatment stratification.
Int J Cancer. 2016 Apr 1;138(7):1765-76. doi: 10.1002/ijc.29897.
[SKT+16] Stöckel, D., Kehl, T., Trampert, P., Schneider, L., Backes, C., Ludwig, N., Gerasch, A., Kaufmann, M., Gessler, M., Graf, N., Meese, E., Keller, A., Lenhof, H.P.,: Multi-omics Enrichment Analysis using the GeneTrail2 Web Service. Bioinformatics 2016; doi: 10.1093/bioinformatics/btv770
